8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Base Information

Chemical Name:8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CAS No.:1266656-43-2
Molecular Formula:C₂₉H₂₉F₂N₃O₂
Molecular Weight:489.565
Hs Code.:

Synonyms:8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

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Chemical Property of 8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

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Technology Process of 8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

There total 5 articles about 8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 20662-52-6
4,4-bis(4-fluorophenyl)butanoic acid

: 1021-25-6
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

: 1266656-43-2
8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2010.11.029

Reference yield:

: 50337-85-4
4,4-bis(4-fluorophenyl)butan-1-ol

: 1266656-43-2
8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: chromium(VI) oxide; sulfuric acid / acetone / 16 h / 0 - 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; tert-butyl alcohol / 16 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1021/acschemneuro.1c00099

Reference yield:

: 4,4-di(4-fluorophenyl)-but-3-en-1-ol

: 1266656-43-2
8-(4,4-bis(4-fluorophenyl)butanoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium on activated charcoal / ethanol / 20 h / 20 °C / Inert atmosphere

2: chromium(VI) oxide; sulfuric acid / acetone / 16 h / 0 - 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; tert-butyl alcohol / 16 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; sulfuric acid; palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1021/acschemneuro.1c00099