(3R,4R)-3-<(1'R,3'S)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2

Base Information

Chemical Name:(3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2
CAS No.:107699-38-7
Molecular Formula:C₂₆H₃₇NO₅Si
Molecular Weight:471.669
Hs Code.:

Synonyms:(3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2

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Chemical Property of (3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2

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Technology Process of (3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2

There total 3 articles about (3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 107699-36-5
methyl (2R*,3R*,5S*)-6-acetoxy-3-hydroxy-5-tert-butyldimethylsilyloxy-2-(R*-p-methoxyphenyl-N-phenylaminomethyl)-hexanoate

: 107699-38-7
(3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2

Guidance literature:: With tert-butylmagnesium chloride; In tetrahydrofuran; Ambient temperature;

Reference yield:

: 102972-08-7
(3R*,3aR*,6S*,7aR*)-6-acetoxymethyl-3-p-methoxyphenyl-4-oxo-2-phenyl-tetrahydropyrano-<3,4-d>-isoxazolidine

: 107699-38-7
(3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / 10percent Pd/C / 7 h / 50 °C / 3800 Torr

2: 63.5 percent / imidazole / dimethylformamide / Ambient temperature

3: 35 percent / t-BuMgCl / tetrahydrofuran / Ambient temperature

With 1H-imidazole; tert-butylmagnesium chloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 107699-35-4
methyl (2R*,3R*,5S*)-6-acetoxy-3,5-dihydroxy-2-(R*-p-methoxyphenyl-N-phenylaminomethyl)-hexanoate

: 107699-38-7
(3R*,4R*)-3-<(1'R*,3'S*)-1',4'-dihydroxy-3'-tert-butyldimethylsilyloxybutyl>-4-p-methoxyphenyl-1-phenylazetidinone-2

Guidance literature:: Multi-step reaction with 2 steps

1: 63.5 percent / imidazole / dimethylformamide / Ambient temperature

2: 35 percent / t-BuMgCl / tetrahydrofuran / Ambient temperature

With 1H-imidazole; tert-butylmagnesium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;