Technology Process of (2R,3S)-3-benzyloxy-2-methoxymethoxymethyltetrahydropyran
There total 26 articles about (2R,3S)-3-benzyloxy-2-methoxymethoxymethyltetrahydropyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
for 17h;
Ambient temperature;
DOI:10.1248/cpb.37.2391
- Guidance literature:
-
Multi-step reaction with 13 steps
1: Et3N
2: NaI, NaHCO3 / acetone
3: NaH / dimethylformamide
4: 87 percent / NaCl / dimethylsulfoxide; H2O / 190 °C
5: 90 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
6: 93 percent / imidazole / dimethylformamide / 3 h / Ambient temperature
7: 93 percent / H2O; acetic acid / 17 h / Ambient temperature
8: 93 percent / Et3N / toluene / 3 h / Heating
9: 39.42 g / Et3N / CH2Cl2 / 1 h / Ambient temperature
10: Bu4NF / tetrahydrofuran / 14 h / Ambient temperature
11: 97 percent / tert-BuOK / 2-methyl-propan-2-ol / 4 h / 40 °C
12: 91 percent / p-TsOH(H2O) / methanol / 1 h / Heating
13: 75 percent / 55percent NaH / dimethylformamide / 17 h / Ambient temperature
With
1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; triethylamine; sodium iodide; sodium chloride;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
DOI:10.1248/cpb.37.2391
- Guidance literature:
-
Multi-step reaction with 13 steps
1: Et3N
2: NaI, NaHCO3 / acetone
3: NaH / dimethylformamide
4: NaCl / dimethylsulfoxide; H2O / 190 °C
5: LiAlH4 / tetrahydrofuran / Ambient temperature
6: imidazole / dimethylformamide / Ambient temperature
7: H2O; acetic acid / Ambient temperature
8: Et3N / toluene / Heating
9: Et3N / CH2Cl2 / Ambient temperature
10: Bu4NF / tetrahydrofuran / Ambient temperature
11: tert-BuOK / 2-methyl-propan-2-ol / 40 °C
12: p-TsOH(H2O) / methanol / Heating
13: 55percent NaH / dimethylformamide / Ambient temperature
With
1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; triethylamine; sodium iodide; sodium chloride;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
DOI:10.1248/cpb.37.2391
