4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide

Base Information

Chemical Name:4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide
CAS No.:1012056-34-6
Molecular Formula:C₂₃H₂₈N₄O₅S₂
Molecular Weight:504.631
Hs Code.:

Synonyms:4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide

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Chemical Property of 4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide

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Technology Process of 4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide

There total 7 articles about 4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1012059-88-9
methyl 4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)butanoate

: 1012056-34-6
4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 0 - 20 ℃; for 0.025h;

Reference yield:

: 13547-70-1
1-chloro-3,3-dimethyl-butan-2-one

: 1012056-34-6
4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium azide / acetone / 25 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol

3.1: triethylamine / dichloromethane / 1.25 h / -10 - -5 °C

4.1: trichlorophosphate / 1 h / 105 °C

5.1: ethanol; sodium tetrahydroborate / acetone / 1 h / 20 °C

5.2: 1 h / Reflux

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 40 °C

7.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0.03 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; sodium azide; ethanol; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; trichlorophosphate; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 76779-98-1
1-azido-3,3-dimethyl-2-butanone

: 1012056-34-6
4-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)-2-oxoethyl)phenoxy)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol

2.1: triethylamine / dichloromethane / 1.25 h / -10 - -5 °C

3.1: trichlorophosphate / 1 h / 105 °C

4.1: ethanol; sodium tetrahydroborate / acetone / 1 h / 20 °C

4.2: 1 h / Reflux

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 40 °C

6.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0.03 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; trichlorophosphate; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;