tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate
CAS No.:945625-46-7
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate

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Chemical Property of tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate

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Technology Process of tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate

There total 2 articles about tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 500220-28-0
Boc-L-phenylalanine-L-threonine methyl ester

: 945625-46-7
tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -20 ℃; for 1.5h;
DOI:10.1039/b701999h

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 945625-46-7
tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / N-methylmorpholine; 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / tetrahydrofuran; dimethylformamide / 20.5 h / 0 - 20 °C

2: 71 percent / Deoxo-Fluor / CH₂Cl₂ / 1.5 h / -20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b701999h

Reference yield:

: 945625-46-7
tert-butyl (S)-1-((4S,5S)-4-(methoxycarbonyl)-4,5-dihydro-5-methyloxazol-2-yl)-2-phenylethylcarbamate

: (4R,5S)-2-(1-amino-2-phenyl-ethyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid triflate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / sodium hydroxide / tetrahydrofuran; H₂O / 3 h / 20 °C

2: CH₂Cl₂ / 1.5 h / 0 °C

With sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/b701999h