N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Base Information

Chemical Name:N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
CAS No.:1402598-59-7
Molecular Formula:C₃₂H₂₇F₃N₂O₅S₂
Molecular Weight:640.704
Hs Code.:

N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Synonyms:N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Chemical Property of N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

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Technology Process of N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

There total 5 articles about N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402599-42-1
N-(phenylmethylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

: 1402599-48-7
2-(2-(1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402598-59-7
N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: 2-(2-(1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1-trifluoro-2-propanol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

N-(phenylmethylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide; In tetrahydrofuran; hexane; for 0.0833333h;

Reference yield:

: 23794-15-2
1-(2-chloropyridin-4-yl)ethan-1-one

: 1402598-59-7
N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride / 1,2-dimethoxyethane / -78 - 20 °C

1.2: 20 h / 20 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

3.2: 0.08 h

With n-butyllithium; caesium carbonate; cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water;

Reference yield:

: 1402599-08-9
2-(2-chloro-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402598-59-7
N-(phenyl(7-(4-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 0.08 h

With n-butyllithium; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexane; water;