(E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester

Base Information

Chemical Name:(E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester
CAS No.:115118-19-9
Molecular Formula:C₂₁H₁₉NO₆
Molecular Weight:381.385
Hs Code.:

Synonyms:(E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester

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Chemical Property of (E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester

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Technology Process of (E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester

There total 7 articles about (E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107377-40-2,115118-18-8
(1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-ol

: 104715-42-6
(E)-4-Isocyanato-but-2-enoic acid methyl ester

: 115118-19-9
(E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester

Guidance literature:: With tetrachloromethane; triphenyl-tin acetate; In dichloromethane; at 0 ℃; Yield given;
DOI:10.1021/jo00251a003

Reference yield:

: 115140-89-1
3-(6-Bromo-benzo[1,3]dioxol-5-yl)-3-phenyl-propionic acid

: 115118-19-9
(E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: TsOH*H₂O

2: 36 percent / NaNH₂, / tetrahydrofuran; NH₃ / 0.13 h / -78 °C

3: 8.14 g / 50percent aq. NaOH / dimethylsulfoxide / 4 h

4: 54 percent / tetrahydrofuran / 1 h

5: acethyl chloride, methanol / CH₂Cl₂ / 3 h / 0 °C

6: triphenyltin acetate, CCl₄ / CH₂Cl₂ / 0 °C

With methanol; tetrachloromethane; sodium hydroxide; triphenyl-tin acetate; toluene-4-sulfonic acid; sodium amide; acetyl chloride; In tetrahydrofuran; dichloromethane; ammonia; dimethyl sulfoxide;
DOI:10.1021/jo00251a003

Reference yield:

: 107377-37-7,115118-16-6
trans-2-phenyl-4,5-(methylenodioxy)benzocyclobutene-1-carboxylic acid

: 115118-19-9
(E)-4-((1R,2S)-2-Phenyl-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino)-but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / tetrahydrofuran / 1 h

2: acethyl chloride, methanol / CH₂Cl₂ / 3 h / 0 °C

3: triphenyltin acetate, CCl₄ / CH₂Cl₂ / 0 °C

With methanol; tetrachloromethane; triphenyl-tin acetate; acetyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00251a003