2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole

Base Information

Chemical Name:2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole
CAS No.:114772-75-7
Molecular Formula:C₂₃H₂₇ClN₂O₂
Molecular Weight:398.933
Hs Code.:

Synonyms:2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole

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Chemical Property of 2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole

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Technology Process of 2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole

There total 13 articles about 2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 114772-50-8
2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(methoxymethyl)imidazole

: 114772-75-7
2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114772-75-7
2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

7: 4.77 g / Na / 18 h / 25 °C

8: 90 percent / 1.0 M lithium aluminum hydride / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; thionyl chloride; sodium methylate; sodium; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform;
DOI:10.1021/jm00112a031

Reference yield:

: 624-31-7
4-tolyl iodide

: 114772-75-7
2-butyl-4-chloro-1-<<2'-(hydroxymethyl)biphenyl-4-yl>methyl>-5-(methoxymethyl)imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 97 percent / thionyl chloride / CHCl₃ / 4 h / 25 °C

5: 4.77 g / Na / 18 h / 25 °C

6: 90 percent / 1.0 M lithium aluminum hydride / tetrahydrofuran / 2 h / Heating

With N-Bromosuccinimide; lithium aluminium tetrahydride; thionyl chloride; sodium methylate; sodium; copper; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform;
DOI:10.1021/jm00112a031