1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine

Base Information

Chemical Name:1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
CAS No.:123947-19-3
Molecular Formula:C₂₇H₃₂N₂O₇S
Molecular Weight:528.626
Hs Code.:

Synonyms:1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine

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Chemical Property of 1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine

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Technology Process of 1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine

There total 10 articles about 1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123947-71-7
7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carboxylic acid

: 1-(3,4,5-trimethoxybenzoyl)piperazine hydrochloride

: 123947-19-3
1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; triethylamine; In dichloromethane; toluene;

Reference yield:

: 700-96-9
3,4-dimethoxythiophenol

: 123947-19-3
1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) 2.5 M NaOEt / 1.) EtOH, reflux, 10 min, 2.) EtOH, reflux, 3 h

2: 92 percent / PPA / 2 h / 100 °C

3: 80 percent / NaOCH₃ / 8 h / Heating

4: NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / Ambient temperature

5: 10percent NaOH / methanol / 1 h / Ambient temperature

6: conc. HCl / dioxane / 0.67 h / 90 °C

7: SOCl₂ / toluene / 0.5 h / 100 °C

8: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium methylate; sodium ethanolate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1248/cpb.42.541

Reference yield:

: 60169-43-9
7,8-dimethoxy-2,3,4,5-tetrahydro-1-benzothiepin-5-one

: 123947-19-3
1-(7,8-dimethoxy-2,3-dihydro-1-benzothiepin-4-carbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / NaOCH₃ / 8 h / Heating

2: NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / Ambient temperature

3: 10percent NaOH / methanol / 1 h / Ambient temperature

4: conc. HCl / dioxane / 0.67 h / 90 °C

5: SOCl₂ / toluene / 0.5 h / 100 °C

6: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium methylate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1248/cpb.42.541