ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

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Chemical Name:ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate
CAS No.:1242441-14-0
Molecular Formula:C₁₇H₁₈FIN₂O₂
Molecular Weight:428.245
Hs Code.:

Synonyms:ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

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Chemical Property of ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

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Technology Process of ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

There total 5 articles about ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242441-15-1
ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

: 1242441-14-0
ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

Guidance literature:: ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate; With N-iodo-succinimide; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1242441-14-0
ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

1.2: 1 h / 20 °C

1.3: 4 h / Reflux

2.1: hydrogenchloride / methanol / 2 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

4.1: N-iodo-succinimide; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; ethylmagnesium bromide; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml4000996

Reference yield:

: 1242440-99-8
(1S,2S)-ethyl 2-(4-(1-trityl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

: 1242441-14-0
ethyl (1S,2S)-2-{4-[1-(2-fluoroethyl)-5-iodo-1H-imidazol-4-yl]phenyl}cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 2 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

3: N-iodo-succinimide; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; caesium carbonate; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml4000996