2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline

Base Information

Chemical Name:2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline
CAS No.:1362623-11-7
Molecular Formula:C₂₀H₁₉FN₂OS
Molecular Weight:354.448
Hs Code.:

Synonyms:2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline

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Chemical Property of 2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline

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Technology Process of 2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline

There total 2 articles about 2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 473706-11-5
4-(4-fluorophenyl)-tetrahydro-2H-pyran-4-carboxylic acid

: 2454-39-9
2-aminobenzothioamide

: 1362623-11-7
2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline

Guidance literature:: 4-(4-fluorophenyl)-tetrahydro-2H-pyran-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.333333h;

2-aminobenzothioamide; In pyridine; at 20 ℃;

With methanol; sodium methylate; methyl iodide; In ethanol; at 20 - 65 ℃; for 0.75h;

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 1362623-11-7
2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: Lawessons reagent / tetrahydrofuran / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.33 h / 20 °C

2.2: 20 °C

2.3: 0.75 h / 20 - 65 °C

With Lawessons reagent; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield: 11.0%

: 31230-17-8
3-methyl-5-aminopyrazole

: 1362623-11-7
2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline

: 1362622-65-8
2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

Guidance literature:: 2-(4-(4-fluorophenyl)tetrahydro-2H-pyran-4-yl)-4-(methylthio)quinazoline; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;

3-methyl-5-aminopyrazole; In tetrahydrofuran; at 60 ℃;