diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

Base Information

Chemical Name:diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate
CAS No.:1621887-45-3
Molecular Formula:C₃₇H₃₄F₂N₅O₇PS
Molecular Weight:761.743
Hs Code.:

diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

Synonyms:diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

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Chemical Property of diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

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Technology Process of diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

There total 9 articles about diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.4%

: 1621888-95-6
5-(6-(chloromethyl)-11-fluoropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 122-52-1
triethyl phosphite

: 1621887-45-3
diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

Guidance literature:: at 80 - 140 ℃; for 3.5h;

Reference yield:

: 400777-06-2
6-chloro-2-iodopyridin-3-amine

: 1621887-45-3
diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 70 °C / Inert atmosphere

2: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

3: trifluoroacetic acid / 1,4-dioxane / 3 h / 85 °C

4: 3.5 h / 80 - 140 °C

With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;

Reference yield:

: 1256359-96-2
4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1621887-45-3
diethyl ((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido [3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 70 °C / Inert atmosphere

2: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

3: trifluoroacetic acid / 1,4-dioxane / 3 h / 85 °C

4: 3.5 h / 80 - 140 °C

With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; water; 1: |Suzuki Coupling / 2: |Suzuki Coupling;