5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

Base Information

Chemical Name:5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole
CAS No.:1426385-33-2
Molecular Formula:C₂₄H₃₃ClN₂O₂Si
Molecular Weight:445.077
Hs Code.:

Synonyms:5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

Suppliers and Price of 5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

There total 5 articles about 5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1426385-32-1
5-(benzyloxymethyl)-3-(1-(triisopropylsilyl)-1H-pyrrol-2-yl)isoxazole

: 1426385-33-2
5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

Guidance literature:: With N-chloro-succinimide; palladium diacetate; In acetonitrile; at 80 ℃; Inert atmosphere;
DOI:10.1021/ja400473v

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1426385-33-2
5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydride; 18-crown-6 ether / mineral oil; tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: N-chloro-succinimide; palladium diacetate / acetonitrile / 7 h / 20 - 85 °C / Darkness; Inert atmosphere

With N-chloro-succinimide; 18-crown-6 ether; palladium diacetate; potassium hydride; In tetrahydrofuran; acetonitrile; mineral oil;
DOI:10.1016/j.tetlet.2013.03.034

Reference yield:

: 1220521-45-8
5-(benzyloxymethyl)-3-bromoisoxazole

: 1426385-33-2
5-(benzyloxymethyl)-(3-chloro-1-(triisopropylsilyl)-1H-pyrrol-2-yl)-isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride; zinc(II) chloride / mineral oil; N,N-dimethyl-formamide / 0 °C / Schlenk technique; Inert atmosphere

1.2: 16 h / 100 °C / Darkness

2.1: potassium hydride; 18-crown-6 ether / mineral oil; tetrahydrofuran / 1.25 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: N-chloro-succinimide; palladium diacetate / acetonitrile / 7 h / 20 - 85 °C / Darkness; Inert atmosphere

With N-chloro-succinimide; 18-crown-6 ether; palladium diacetate; potassium hydride; sodium hydride; zinc(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.tetlet.2013.03.034