methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

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Chemical Name:methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate
CAS No.:1352212-24-8
Molecular Formula:C₄₀H₄₆N₁₀O₈
Molecular Weight:794.867
Hs Code.:

methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

Synonyms:methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

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Chemical Property of methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

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Technology Process of methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

There total 14 articles about methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007880-17-2
(S)-3-methoxy-2-((methoxycarbonyl)amino)propanoic acid

: 2-[(2S)-pyrrolidin-2-yl]-5-[5-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)pyrazin-2-yl]-1H-benzimidazole hydrochloride

: 1352212-24-8
methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

Guidance literature:: (S)-3-methoxy-2-((methoxycarbonyl)amino)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 0.333333h;

2-[(2S)-pyrrolidin-2-yl]-5-[5-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)pyrazin-2-yl]-1H-benzimidazole hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1352212-24-8
methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 - 20 °C

2.1: ammonium acetate / xylenes / 5 h / 150 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

4.1: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 120 °C

5.1: hydrogenchloride / 1,4-dioxane; ethanol / 16 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

6.2: 3 h / 20 °C

With hydrogenchloride; potassium phosphate; ammonium acetate; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile; xylenes;

Reference yield:

: 1007882-04-3
(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1352212-24-8
methyl {(2S)-3-methoxy-1-[(2S)-2-(5-{4-[5-(2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-seryl]pyrrolidin-2-yl}-1H-benzimidazol-6-yl)pyrazin-2-yl]phenyl}-1H-imidazol-2-yl)pyrrolidin-1-yl]-1-oxopropan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

2.1: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 120 °C

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 16 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

4.2: 3 h / 20 °C

With hydrogenchloride; potassium phosphate; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; ethanol; water; acetonitrile;