ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate

Base Information

Chemical Name:ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate
CAS No.:83085-98-7
Molecular Formula:C₂₈H₂₆O₇S
Molecular Weight:506.576
Hs Code.:

Synonyms:ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate

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Chemical Property of ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate

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Technology Process of ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate

There total 5 articles about ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.6%

: 27612-42-6
3,4-dihydro-2H-1,5-benzodioxepin-3-spirooxirane

: 83085-92-1
ethyl 4-(4'-mercapto<1,1'-biphenyl>-4-yl)-2,4-dioxobutanoate

: 83085-98-7
ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate

Guidance literature:: With triethylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm00362a020

Reference yield:

: 13021-17-5
1-(4'-hydroxybiphenyl-4-yl)ethanone

: 83085-98-7
ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) RT, overnight

2: 90.3 percent / 2 h / 255 - 260 °C

3: 49.4 percent / 2 N NaOH / methanol / 6 h / Heating

4: 84 percent / NaOEt / ethanol; dimethylformamide / 3 h / Ambient temperature

5: 75.6 percent / Et₃N / tetrahydrofuran / Ambient temperature

With sodium hydroxide; sodium ethanolate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00362a020

Reference yield:

: 83085-91-0
4-acetyl-4'-mercapto<1,1'-biphenyl>

: 83085-98-7
ethyl 4-<4'-<<(3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl)methyl>thio><1,1'-biphenyl>-4-yl>-2,4-dioxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / NaOEt / ethanol; dimethylformamide / 3 h / Ambient temperature

2: 75.6 percent / Et₃N / tetrahydrofuran / Ambient temperature

With sodium ethanolate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00362a020