N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester

Base Information

Chemical Name:N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester
CAS No.:1310361-09-1
Molecular Formula:C₄₀H₄₈N₂O₅Si
Molecular Weight:664.917
Hs Code.:

Synonyms:N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester

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Chemical Property of N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester

Chemical Property:

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Technology Process of N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester

There total 4 articles about N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310361-08-0
N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanine

: 2748-02-9,13081-32-8
L-leucine tert-butyl ester hydrochloride

: 1310361-09-1
N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.3390/molecules16064695

Reference yield:

: 1310360-88-3
2-(triphenylsilyl)ethyl chloroformate

: 1310361-09-1
N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 5 h / 0 - 20 °C

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

With sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules16064695

Reference yield:

: 18666-87-0
1,1,1-triphenyl-1-silapropan-3-ol

: 1310361-09-1
N-(2-(triphenylsilyl)ethoxy)carbonyl-L-phenylalanyl-L-leucine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene / 4.33 h / 0 - 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / 1,4-dioxane; water / 5 h / 0 - 20 °C

3: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

With sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;
DOI:10.3390/molecules16064695