(2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene

Base Information

Chemical Name:(2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene
CAS No.:168846-63-7
Molecular Formula:C₃₅H₄₄N₂O₄
Molecular Weight:556.745
Hs Code.:

Synonyms:(2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene

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Chemical Property of (2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene

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Technology Process of (2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene

There total 12 articles about (2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1004316-38-4
(3-benzenesulfonyl-1-benzyl-4-tert-butoxycarbonylamino-2-hydroxy-5-phenyl-pentyl)-benzyl-carbamic acid tert-butyl ester

: 168846-63-7
(2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 2.7 g / Na₂HPO₄; Na-Hg / methanol / 12 h / 0 - 20 °C

With pyridine; disodium hydrogenphosphate; sodium amalgam; In methanol; dichloromethane; 1: Acetylation / 2: Elimination;
DOI:10.1016/S0040-4020(97)00160-9

Reference yield:

: acetic acid 2-benzenesulfonyl-1-[1-(benzyl-tert-butoxycarbonyl-amino)-2-phenyl-ethyl]-3-tert-butoxycarbonylamino-4-phenyl-butyl ester

: 168846-63-7
(2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 - 20 ℃; for 12h;
DOI:10.1016/S0040-4020(97)00160-9

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 168846-63-7
(2S,5S,3E)-2-[(1,1-dimethylethoxy)carbonyl]amino-5-{[(1,1-dimethylethoxy)carbonyl]-N-benzyl}amino-1,6-diphenylhex-3-ene

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaBH₄; I₂ / tetrahydrofuran / 18 h / Heating

2.1: 95 percent / tetrahydrofuran; H₂O / 1 h / 20 °C

3.1: 90 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 83 percent / methanol; tetrahydrofuran / 3 h / 20 °C

5.1: 95 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 20 °C

6.1: n-BuLi / tetrahydrofuran / -78 °C

6.2: MeOH; DIBAL-H / tetrahydrofuran; hexane / 0.5 h / -78 °C

7.1: pyridine / CH₂Cl₂ / 12 h / 20 °C

8.1: 2.7 g / Na₂HPO₄; Na-Hg / methanol / 12 h / 0 - 20 °C

With pyridine; sodium tetrahydroborate; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; iodine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: Reduction / 2.1: alkoxycarbonylation / 3.1: Tosylation / 4.1: Substitution / 5.1: Oxidation / 6.1: Metallation / 6.2: Addition / 7.1: Acetylation / 8.1: Elimination;
DOI:10.1016/S0040-4020(97)00160-9