(R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid

Base Information

Chemical Name:(R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid
CAS No.:1047668-27-8
Molecular Formula:C₁₈H₁₇Cl₂NO₄S
Molecular Weight:414.309
Hs Code.:

Synonyms:(R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid

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Chemical Property of (R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid

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Technology Process of (R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid

There total 5 articles about (R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1047668-31-4
C₁₉H₁₉Cl₂NO₄S

: 1047668-27-8
(R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid

Guidance literature:: C₁₉H₁₉Cl₂NO₄S; With lithium hydroxide; water; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 1047668-28-9
C₁₈H₂₇Cl₂NO₂Si

: 1047668-27-8
(R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 0.17 h

3.1: lithium hydroxide; water / tetrahydrofuran

With lithium hydroxide; tetrabutyl ammonium fluoride; water; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 128899-30-9,100548-49-0,106191-02-0
(R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one

: 1047668-27-8
(R)-5-(((1-(3,5-dichlorobenzyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 18 h / 40 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 0.17 h

4.1: lithium hydroxide; water / tetrahydrofuran

With lithium hydroxide; tetrabutyl ammonium fluoride; water; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;