α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid

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Chemical Name:α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid
CAS No.:384833-18-5
Molecular Formula:C₂₀H₁₇N₃O₃S₂
Molecular Weight:411.505
Hs Code.:

Synonyms:α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid

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Chemical Property of α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid

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Technology Process of α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid

There total 5 articles about α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 4870-65-9,31302-84-8
2-bromophenylacetic acid

: 384833-17-4
2,3-dihydro-5,6-dimethyl-3-(1H-pyrrol-1-yl)-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one

: 384833-18-5
α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid

Guidance literature:: With triethylamine; In benzene; at 20 ℃; for 24h;

Reference yield:

: 85716-85-4
ethyl 2-isothiocyanato-4,5-dimethylthiophene-3-carboxylate

: 384833-18-5
α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NH₂NH₂*H₂O / CHCl₃ / 2 h / 20 °C

2: NaOH / ethanol / 0.5 h / Heating

3: 40 percent / AcOH / 3 h / Heating

4: 50 percent / Et₃N / benzene / 24 h / 20 °C

With sodium hydroxide; hydrazine hydrate; acetic acid; triethylamine; In ethanol; chloroform; benzene;

Reference yield:

: 4815-24-1
2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester

: 384833-18-5
α-(+/-)-[(3,4-dihydro-5,6-dimethyl-4-oxo-3-(1H-pyrrol-1-yl)-thieno[2,3-d]pyrimidin-2-yl)thio]phenylacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / acetone / 0.25 h / 20 °C

2: 75 percent / NH₂NH₂*H₂O / CHCl₃ / 2 h / 20 °C

3: NaOH / ethanol / 0.5 h / Heating

4: 40 percent / AcOH / 3 h / Heating

5: 50 percent / Et₃N / benzene / 24 h / 20 °C

With sodium hydroxide; hydrazine hydrate; acetic acid; triethylamine; In ethanol; chloroform; acetone; benzene;