(3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone

Base Information

Chemical Name:(3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone
CAS No.:1380507-20-9
Molecular Formula:C₂₀H₁₇F₂N₃O₂
Molecular Weight:369.371
Hs Code.:

Synonyms:(3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone

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Chemical Property of (3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone

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Technology Process of (3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone

There total 7 articles about (3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1380507-34-5
5-(4-fluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-pyrazolo[1,5-a]pyrazine

: 1380507-20-9
(3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone

Guidance literature:: With Selectfluor; In acetonitrile; at 80 ℃; for 16h;

Reference yield:

: 1380507-24-3
diethyl 1-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-pyrazole-3,5-dicarboxylate

: 1380507-20-9
(3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 120 °C / Inert atmosphere; sealed tube; microwave irradiation

5.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / 90 °C / sealed tube; Inert atmosphere

6.1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

7.1: Selectfluor / acetonitrile / 16 h / 80 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; di-tert-butyl-diazodicarboxylate; ammonium formate; sodium hydride; Selectfluor; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1338563-40-8
ethyl 5-benzyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

: 1380507-20-9
(3-fluoro-2-phenoxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl)-(4-fluoro-phenyl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 120 °C / Inert atmosphere; sealed tube; microwave irradiation

3: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / 90 °C / sealed tube; Inert atmosphere

4: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5: Selectfluor / acetonitrile / 16 h / 80 °C

With pyridine; lithium aluminium tetrahydride; di-tert-butyl-diazodicarboxylate; ammonium formate; Selectfluor; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;