5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide

Base Information

Chemical Name:5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide
CAS No.:1409946-73-1
Molecular Formula:C₁₃H₁₅FN₄OS
Molecular Weight:294.353
Hs Code.:

Synonyms:5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide

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Chemical Property of 5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide

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Technology Process of 5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide

There total 3 articles about 5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1409946-72-0
5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carbonitrile

: 1409946-73-1
5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide

Guidance literature:: With water; dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; at 0 ℃; for 0.25h; Cooling with ice;

Reference yield:

: 2-(4-fluoro-phenyl)-2-methyl-propionitrile

: 1409946-73-1
5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / Reflux

2.1: dichloromethane / 0 - 20 °C

2.2: 20 °C

3.1: N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Sealed vial

4.1: potassium carbonate; water; dihydrogen peroxide / dimethyl sulfoxide / 0.25 h / 0 °C / Cooling with ice

With lithium aluminium tetrahydride; water; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 2-methyl-2-(4-fluorophenyl)propylamine

: 1409946-73-1
5-{[2-(4-Fluorophenyl)-2-methylpropyl]amino}-1,2,4-thiadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0 - 20 °C

1.2: 20 °C

2.1: N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Sealed vial

3.1: potassium carbonate; water; dihydrogen peroxide / dimethyl sulfoxide / 0.25 h / 0 °C / Cooling with ice

With water; dihydrogen peroxide; potassium carbonate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;