5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

Base Information

Chemical Name:5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine
CAS No.:1377550-33-8
Molecular Formula:C₂₈H₃₀N₆O₂S
Molecular Weight:514.651
Hs Code.:

Synonyms:5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

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Chemical Property of 5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

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Technology Process of 5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

There total 5 articles about 5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 7752-82-1
5-bromo-2-aminopyrimidine

: 1377551-58-0
1-(2-(4-isopropylphenyl)pyridin-3-yl)-4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfonyl)piperazine

: 1377550-33-8
5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 1h;
DOI:10.1021/jm300403a

Reference yield:

: 52200-48-3
3-bromo-2-chloropyridine

: 1377550-33-8
5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / toluene / 2 h / 100 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 90 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,2-dimethoxyethane / 1 h / 90 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 90 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; toluene; 2: Suzuki-Miyaura cross-coupling / 5: Suzuki-Miyaura cross-coupling / 6: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a

Reference yield:

: 2905-24-0
3-Bromobenzenesulfonyl chloride

: 1377550-33-8
5-(3-(4-(2-(4-isopropylphenyl)pyridin-3-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,2-dimethoxyethane / 1 h / 90 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 90 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki-Miyaura cross-coupling / 3: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a