(2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone

Base Information

• Chemical Name: (2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone
• CAS No.: 1395408-82-8
• Molecular Formula: C₁₂H₁₄N₂O₆
• Molecular Weight: 282.253
• Mol file: 1395408-82-8.mol

Synonyms:(2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone

Chemical Property of (2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone

There total 4 articles about (2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(2-nitrovinyl)furan (699-18-3,32782-45-9) + 2-nitrocyclohexanone (4883-67-4) → (2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone (1395408-82-8)

Guidance literature:

2-nitrocyclohexanone; With (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-tert-butylpiperidine-3-yl)thiourea; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

2-(2-nitrovinyl)furan; In dichloromethane; at 0 ℃; for 17h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol302005f

Reference yield:

2-(2-nitrovinyl)furan (699-18-3,32782-45-9) + 2-nitrocyclohexanone (4883-67-4) → (2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone (1395408-82-8) + (RS)-2-[(SR)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone

Guidance literature:

With (S)-1-benzyl-3-(1-tert-butylpiperidine-3-yl)thiourea; for 0.75h; Overall yield = 86 %; Milling;

DOI:10.1039/c2gc36906k

Reference yield:

2-(2-nitrovinyl)furan (699-18-3,32782-45-9) + 2-nitrocyclohexanone (4883-67-4) → (2S)-2-[(1S)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone (1395408-82-8) + (R)-2-[(R)-1-(furan-2-yl)-2-nitroethyl]-2-nitrocyclohexanone

Guidance literature:

With (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-methylpiperidine-3-yl)thiourea; for 0.75h; Overall yield = 83 %; Milling;

DOI:10.1039/c2gc36906k

upstream raw materials:

2-(2-nitrovinyl)furan

2-nitrocyclohexanone