4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid

Base Information

Chemical Name:4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid
CAS No.:1429874-83-8
Molecular Formula:C₃₇H₃₁Cl₃N₂O₄
Molecular Weight:674.023
Hs Code.:

Synonyms:4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid

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Chemical Property of 4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid

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Technology Process of 4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid

There total 4 articles about 4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1429878-98-7
2-[2-(3-amino-3-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}propyl)phenyl]propan-2-ol

: 56962-07-3
3,4-dichlorophthalic anhydride

: 1429874-83-8
4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid

Guidance literature:: In dichloromethane; at 25 - 30 ℃; for 3h;

Reference yield:

: 1079753-36-8
C₂₉H₂₈ClNO₂

: 1429874-83-8
4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / toluene; acetonitrile / 3 h / -25 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 12 h / 20 °C

3: triphenylphosphine; water / tetrahydrofuran / 36 h / 20 °C

4: dichloromethane / 3 h / 25 - 30 °C

With sodium azide; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1429878-96-5
C₃₀H₃₀ClNO₄S

: 1429874-83-8
4,5-dichloro-N-{1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}phthalamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 20 °C

2: triphenylphosphine; water / tetrahydrofuran / 36 h / 20 °C

3: dichloromethane / 3 h / 25 - 30 °C

With sodium azide; water; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;