5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride

Base Information

Chemical Name:5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride
CAS No.:603124-25-0
Molecular Formula:C₂₆H₂₆ClNO₄*ClH
Molecular Weight:488.411
Hs Code.:

Synonyms:5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride

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Chemical Property of 5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride

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Technology Process of 5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride

There total 13 articles about 5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₄ClNO₆

: 603124-25-0
5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 1048330-10-4
[3-(methoxycarbonyl)-4-methylphenyl] boronic acid

: 603124-25-0
5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

2: methanol; sodium hydroxide; water / 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; water; copper diacetate; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm800222k

Reference yield:

: 603123-25-7
C₃₂H₃₆ClNO₆

: 603124-25-0
5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-2-methylbenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium hydroxide; water / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; water; In 1,4-dioxane;
DOI:10.1021/jm800222k