benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate

Base Information

• Chemical Name: benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate
• CAS No.: 863660-33-7
• Molecular Formula: C₂₄H₃₂N₂O₅
• Molecular Weight: 428.528
• Mol file: 863660-33-7.mol

Synonyms:benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate

Chemical Property of benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate

There total 1 articles about benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

benzyl (2S)-5-allylpyrrolidine-2-carboxylate (863660-23-5) + 2-tert-butoxycarbonylaminobut-3-enoic acid (152468-91-2) + isobutyl chloroformate (543-27-1) → 2-benzyl (2S)-N-iso-butoxycarbonyl-5-allylpyrrolidine-2-carboxylate + benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate (863660-33-7)

Guidance literature:

2-tert-butoxycarbonylaminobut-3-enoic acid; isobutyl chloroformate; With pyridine; In tetrahydrofuran; at 0 ℃; for 0.25h;

benzyl (2S)-5-allylpyrrolidine-2-carboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1039/b503014e

Reference yield: 58.0%

benzyl (2S)-5-allyl-1-(2-tert-butoxycarbonylaminobut-3-enoyl)-pyrrolidine-2-carboxylate (863660-33-7) → 6-tert-butoxycarbonylamino-5-oxo-2,3,5,6,9,9a-hexahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylic acid benzyl ester + 6-tert-butoxycarbonylamino-5-oxo-2,3,5,6,9,9a-hexahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylic acid benzyl ester

Guidance literature:

Grubbs catalyst first generation; In dichloromethane; for 24h; Heating;

DOI:10.1039/b503014e

upstream raw materials:

benzyl (2S)-5-allylpyrrolidine-2-carboxylate

2-tert-butoxycarbonylaminobut-3-enoic acid

isobutyl chloroformate