5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester

Base Information

• Chemical Name: 5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester
• CAS No.: 1094772-24-3
• Molecular Formula: C₂₀H₂₂N₂O₅
• Molecular Weight: 370.405
• Mol file: 1094772-24-3.mol

Synonyms:5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester

Chemical Property of 5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester

There total 1 articles about 5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(2-nitrosophenyl)propionic acid (1094772-18-5) + 5-aminosalicylic acid tert-butyl ester (155388-93-5) → 5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester (1094772-24-3)

Guidance literature:

With acetic acid; for 48.25h;

Reference yield: 70.0%

5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester (1094772-24-3) + 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide (169590-42-5,194044-54-7) → C37H34F3N5O6S (1233497-36-3)

Guidance literature:

5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester; 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; for 24h;

In ethyl acetate; 1,2-dichloro-ethane; tert-butyl alcohol; for 2h;

Reference yield: 43.0%

prednisolon (50-24-8,8056-11-9) + 5-[2-(2-carboxyethyl)phenylazo]-2-hydroxybenzoic acid tert-butyl ester (1094772-24-3) → 5-(2-{2-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxycarbonyl]ethyl}phenylazo)-2-hydroxybenzoic acid tert-butyl ester (1094772-20-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 40 ℃;

DOI:10.1021/jm8016317

upstream raw materials:

3-(2-nitrosophenyl)propionic acid

5-aminosalicylic acid tert-butyl ester

Downstream raw materials:

5-(2-{2-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxycarbonyl]ethyl}phenylazo)-2-hydroxybenzoic acid tert-butyl ester

C₃₇H₃₄F₃N₅O₆S