(S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester

Base Information

Chemical Name:(S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester
CAS No.:95485-12-4
Molecular Formula:C₂₅H₃₀N₈O₆
Molecular Weight:538.563
Hs Code.:

Synonyms:(S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester

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Chemical Property of (S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester

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Technology Process of (S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester

There total 3 articles about (S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95485-10-2
(S)-2-{4-[(4-Amino-2-formimidoylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester 1-methyl ester

: 95485-12-4
(S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester

Guidance literature:: With barium dihydroxide; In ethanol; at 25 ℃; for 22h;
DOI:10.1021/jm50001a021

Reference yield:

: 19741-14-1
4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

: 95485-12-4
(S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) diethyl phosphorocyanidate, Et₃N, 2.) Et₃N / 1.) DMF, 25 deg C, 2.5 h, 2.) DMF, 25 deg C, 70 h

2: aq. Ba(OH)2 / ethanol / 22 h / 25 °C

With barium dihydroxide; diethyl cyanophosphonate; triethylamine; In ethanol;
DOI:10.1021/jm50001a021

Reference yield:

: 6234-01-1,16948-36-0
L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride

: 95485-12-4
(S)-2-{4-[(4-Amino-2-formylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) diethyl phosphorocyanidate, Et₃N, 2.) Et₃N / 1.) DMF, 25 deg C, 2.5 h, 2.) DMF, 25 deg C, 70 h

2: aq. Ba(OH)2 / ethanol / 22 h / 25 °C

With barium dihydroxide; diethyl cyanophosphonate; triethylamine; In ethanol;
DOI:10.1021/jm50001a021