Technology Process of Toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-isopropyl-phenyl) ester
There total 9 articles about Toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-isopropyl-phenyl) ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: KNO3 / 0 - 20 °C
2: aq. K2CO3 / methanol / 16 h / 20 °C
3: 90 percent / NaBr; Br2 / 0 - 20 °C
4: 95 percent / H2 / Raney nickel / tetrahydrofuran / 16 h / 2585.81 Torr
5: 98 percent / ethyl acetate; hexane / 16 h / Heating
6: aq. NaSH; NaBH4 / methanol / 16 h / 20 °C
7: pyridine
With
pyridine; sodium tetrahydroborate; sodium hydrogensulfide; hydrogen; bromine; potassium carbonate; potassium nitrate; sodium bromide;
nickel;
In
tetrahydrofuran; methanol; hexane; ethyl acetate;
1: Nitration / 2: Hydrolysis / 3: thiocyanation / 4: Reduction / 5: Acylation / 6: Reduction / 7: Tosylation;
DOI:10.1021/ol0056170
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / NaBr; Br2 / 0 - 20 °C
2: 95 percent / H2 / Raney nickel / tetrahydrofuran / 16 h / 2585.81 Torr
3: 98 percent / ethyl acetate; hexane / 16 h / Heating
4: aq. NaSH; NaBH4 / methanol / 16 h / 20 °C
5: pyridine
With
pyridine; sodium tetrahydroborate; sodium hydrogensulfide; hydrogen; bromine; sodium bromide;
nickel;
In
tetrahydrofuran; methanol; hexane; ethyl acetate;
1: thiocyanation / 2: Reduction / 3: Acylation / 4: Reduction / 5: Tosylation;
DOI:10.1021/ol0056170
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / H2 / Raney nickel / tetrahydrofuran / 16 h / 2585.81 Torr
2: 98 percent / ethyl acetate; hexane / 16 h / Heating
3: aq. NaSH; NaBH4 / methanol / 16 h / 20 °C
4: pyridine
With
pyridine; sodium tetrahydroborate; sodium hydrogensulfide; hydrogen;
nickel;
In
tetrahydrofuran; methanol; hexane; ethyl acetate;
1: Reduction / 2: Acylation / 3: Reduction / 4: Tosylation;
DOI:10.1021/ol0056170
