(3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol

Base Information

Chemical Name:(3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol
CAS No.:1601460-53-0
Molecular Formula:C₁₅H₁₅BrO₃
Molecular Weight:323.186
Hs Code.:

Synonyms:(3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol

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Chemical Property of (3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol

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Technology Process of (3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol

There total 1 articles about (3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 869732-13-8
3-(benzyloxy)-5-bromo-2-methoxybenzaldehyde

: 1601460-53-0
(3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.020

Reference yield: 80.0%

: 1601460-53-0
(3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol

: 1601460-51-8
1-(benzyloxy)-5-bromo-3-(bromomethyl)-2-methoxybenzene

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.020

Reference yield:

: 1601460-53-0
(3-(benzyloxy)-5-bromo-2-methoxyphenyl)methanol

: 869732-32-1
(2E,6S,7S,8E,10S,11R,12S,14R)-ethyl 15-(3-(benzyloxy)-5-bromo-2-methoxyphenyl)-7-((tert-butyldimethylsilyl)oxy)-6,12-dimethoxy-11-(methoxymethoxy)-2,8,10,14-tetramethylpentadeca-2,8-dienoate

Guidance literature:: Multi-step reaction with 12 steps

1.1: phosphorus tribromide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C / Inert atmosphere

4.1: methanol / 16 h / 55 °C / Inert atmosphere; Molecular sieve

5.1: benzo[1,3,2]dioxaborole / tetrahydrofuran / 2.25 h / 0 - 20 °C / Inert atmosphere

5.2: 12 h / Inert atmosphere; Reflux

6.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 8.5 h / 0 - 20 °C / Inert atmosphere; Molecular sieve

7.1: pyridine hydrogenfluoride; pyridine / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

8.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

8.2: 1 h / -78 - 20 °C / Inert atmosphere

9.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide; dmap / dichloromethane / 8.5 h / 0 °C / Inert atmosphere; Reflux

11.1: Schwartz's reagent / toluene / 6 h / 50 °C / Inert atmosphere

11.2: -78 - 0 °C / Inert atmosphere

11.3: 1 h / 0 °C / Inert atmosphere

12.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; dmap; Schwartz's reagent; oxalyl dichloride; boron trifluoride diethyl etherate; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; diisobutylaluminium hydride; pyridine hydrogenfluoride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; 8.1: |Swern Oxidation / 8.2: |Swern Oxidation;
DOI:10.1016/j.tet.2014.03.020