THK-5105

Base Information

Chemical Name:THK-5105
CAS No.:1587709-76-9
Molecular Formula:C₂₀H₂₁FN₂O₂
Molecular Weight:339.399
Hs Code.:

Synonyms:THK-5105

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of THK-5105

Chemical Property:

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Technology Process of THK-5105

There total 15 articles about THK-5105 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₆N₂O₆S

: 1587709-76-9
THK-5105

Guidance literature:: C₃₂H₃₆N₂O₆S; With potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In water; dimethyl sulfoxide; acetonitrile; at 110 ℃; for 0.166667h; Inert atmosphere;

With hydrogenchloride; In water; dimethyl sulfoxide; acetonitrile; at 110 ℃; for 0.05h; Inert atmosphere;

Reference yield:

: 1587709-90-7
N,N-dimethyl-4-(6-(oxiran-2-ylmethoxy)quinolin-2-yl)aniline

: 1587709-76-9
THK-5105

: C₂₀H₂₁⁽¹⁸⁾FN₂O₂

Guidance literature:: With C₈₀H₁₀₇Co₂⁽¹⁸⁾FN₄O₁₀S; In acetonitrile; at 50 ℃; for 0.333333h; enantioselective reaction;
DOI:10.1021/ja5025645

Reference yield:

: C₂₃H₂₆N₂O₃

: 1587709-76-9
THK-5105

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 1.17 h / 70 °C

2.1: pyridine / tetrahydrofuran / 0.5 h / 0 °C

3.1: toluene-4-sulfonic acid / dichloromethane / 1.5 h / 27 °C

4.1: potassium carbonate; [18F]fluoride ion, cyclotron produced, NCA; [2.2.2]cryptande / water; acetonitrile; dimethyl sulfoxide / 0.17 h / 110 °C / Inert atmosphere

4.2: 0.05 h / 110 °C / Inert atmosphere

With pyridine; hydrogenchloride; potassium carbonate; toluene-4-sulfonic acid; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;