(S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

Base Information

Chemical Name:(S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine
CAS No.:1421788-80-8
Molecular Formula:C₁₉H₂₉NO₃S
Molecular Weight:351.51
Hs Code.:

(S<SUB>S</SUB>, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

Synonyms:(S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

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Technology Process of (S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

There total 1 articles about (S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 289507-40-0
3,3-dimethylbutylene 1,2-episulphoxide

: tert-butyl (R)-2-iodo-1-phenylethyl carbamate

: 1421788-80-8
(S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

: 1421788-81-9
C₁₉H₂₉NO₃S

Guidance literature:: 3,3-dimethylbutylene 1,2-episulphoxide; With lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h; Inert atmosphere;

tert-butyl (R)-2-iodo-1-phenylethyl carbamate; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Overall yield = 65 %; Overall yield = 0.163 g; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo302769b

Reference yield: 77.0%

: 1421788-80-8
(S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

: 1451261-12-3
(1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfonyl)-1-phenylethanamine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol4023003

Reference yield:

: 1421788-80-8
(S_S, 1R)-N-Boc-2-((E)-3,3-dimethyl-1-butenylsulfinyl)-1-phenylethanamine

: 1451261-19-0
(1R)-2-((E)-3,3-dimethyl-1-butenylsulfonyl)-1-phenylethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2.2: pH Ca_. 8

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol4023003