Technology Process of 1,2-di-O-acetyl-3,5-di-O-benzoyl-4-C-(N-trifluoroacetylpiperazinyl)methyl-α,β-D-xylofuranose
There total 8 articles about 1,2-di-O-acetyl-3,5-di-O-benzoyl-4-C-(N-trifluoroacetylpiperazinyl)methyl-α,β-D-xylofuranose which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,5-di-O-benzoyl-1,2-O-isopropylidene-4-C-(N-trifluoroacetylpiperazinyl)methyl-α-D-xylofuranose;
With
trifluoroacetic acid;
at 20 ℃;
for 3h;
acetic anhydride;
With
pyridine;
at 20 ℃;
for 12h;
DOI:10.1002/ejoc.200500023
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 89 percent / ammonium formate / Pd(OH)2/C / methanol / 16 h / Heating
2.1: 93 percent / triethylamine / CH2Cl2 / 36 h / 20 °C
3.1: 86 percent / pyridine / CH2Cl2 / 12 h / 0 - 20 °C
4.1: 93 percent / DMAP; imidazole / dimethylformamide / 12 h / 20 °C
5.1: 90 percent / NH3 / methanol / 24 h / 20 °C
6.1: pyridine; triflic anhydride / CH2Cl2 / 12 h / -30 - 20 °C
6.2: 91 percent / tetrahydrofuran / 12 h / 20 °C
7.1: 87 percent / triethylamine / CH2Cl2 / 4 h / 20 °C
8.1: 2.56 g / tetrabutylammonium fluoride / tetrahydrofuran / 12 h / 20 °C
9.1: 3.84 g / pyridine / CH2Cl2 / 12 h / 20 °C
10.1: aq. trifluoroacetic acid / 3 h / 20 °C
10.2: 91 percent / pyridine / 12 h / 20 °C
With
pyridine; 1H-imidazole; dmap; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; ammonia; ammonium formate; triethylamine; trifluoroacetic acid;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
5.1: Zemplen O-debenzoylation;
DOI:10.1002/ejoc.200500023
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 86 percent / pyridine / CH2Cl2 / 12 h / 0 - 20 °C
2.1: 93 percent / DMAP; imidazole / dimethylformamide / 12 h / 20 °C
3.1: 90 percent / NH3 / methanol / 24 h / 20 °C
4.1: pyridine; triflic anhydride / CH2Cl2 / 12 h / -30 - 20 °C
4.2: 91 percent / tetrahydrofuran / 12 h / 20 °C
5.1: 87 percent / triethylamine / CH2Cl2 / 4 h / 20 °C
6.1: 2.56 g / tetrabutylammonium fluoride / tetrahydrofuran / 12 h / 20 °C
7.1: 3.84 g / pyridine / CH2Cl2 / 12 h / 20 °C
8.1: aq. trifluoroacetic acid / 3 h / 20 °C
8.2: 91 percent / pyridine / 12 h / 20 °C
With
pyridine; 1H-imidazole; dmap; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; ammonia; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
3.1: Zemplen O-debenzoylation;
DOI:10.1002/ejoc.200500023
