3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

Base Information

Chemical Name:3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one
CAS No.:1135026-91-3
Molecular Formula:C₂₂H₂₂ClNO₄
Molecular Weight:399.874
Hs Code.:

Synonyms:3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

Suppliers and Price of 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

There total 8 articles about 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1135036-99-5
C₂₉H₂₈ClNO₄

: 1135026-91-3
3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; ethyl acetate; at 60 ℃;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135033-31-6
C₁₇H₁₂ClNO₂

: 1135026-91-3
3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol

2: pyridine; thionyl chloride / tetrahydrofuran

3: potassium carbonate / N,N-dimethyl-formamide / 80 °C

4: hydrogenchloride / tetrahydrofuran; ethyl acetate / 60 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135033-39-4
C₁₇H₁₄ClNO₂

: 1135026-91-3
3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / tetrahydrofuran

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: hydrogenchloride / tetrahydrofuran; ethyl acetate / 60 °C

With pyridine; hydrogenchloride; thionyl chloride; potassium carbonate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.015