N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine

Base Information

• Chemical Name: N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine
• CAS No.: 1245711-57-2
• Molecular Formula: C₁₂H₁₅BrFNS
• Molecular Weight: 304.226
• Mol file: 1245711-57-2.mol

Synonyms:N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine

Chemical Property of N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine

There total 1 articles about N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tetrahydrothiopyran-4-one (1072-72-6) + 3-bromo-4-fluoro-benzylamine (388072-39-7) → N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine (1245711-57-2)

Guidance literature:

Tetrahydrothiopyran-4-one; 3-bromo-4-fluoro-benzylamine; In chloroform; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In chloroform;

With sodium hydroxide; In chloroform; water;

Reference yield:

N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine (1245711-57-2) + 1-methylimidazole-4-carboxylic acid (41716-18-1) → N-(3-Bromo-4-fluorobenzyl)-1-methyl-N-(tetrahydro-2H-thiopyran-4-yl)-1H-imidazole-4-carboxamide (1245711-59-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

N-(3-bromo-4-fluorobenzyl)tetrahydro-2H-thiopyran-4-amine (1245711-57-2) → N-[[6-fluoro-4'-(trifluoromethoxy)biphenyl-3-yl]methyl]-1-methyl-N-(tetrahydro-2H-thiopyran-4-yl)-1H-imidiazole-4-carboxamide (1245711-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 0.5 h / 150 °C / Microwave irradiation

With benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

Tetrahydrothiopyran-4-one

3-bromo-4-fluoro-benzylamine

Downstream raw materials:

N-(3-Bromo-4-fluorobenzyl)-1-methyl-N-(tetrahydro-2H-thiopyran-4-yl)-1H-imidazole-4-carboxamide

N-[[6-fluoro-4'-(trifluoromethoxy)biphenyl-3-yl]methyl]-1-methyl-N-(tetrahydro-2H-thiopyran-4-yl)-1H-imidiazole-4-carboxamide

N-(1,1-dioxidetetrahydro-2H-thiopyran-4-yl)-N-[[6-fluoro-[4'-(trifluoromethoxy)biphenyl]-3-yl]methyl]-1-methyl-1H-imidiazole-4-carboxamide