(2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane

Base Information

Chemical Name:(2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane
CAS No.:174282-99-6
Molecular Formula:C₂₇H₃₈N₂O₇Si
Molecular Weight:530.693
Hs Code.:

Synonyms:(2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane

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Chemical Property of (2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane

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Technology Process of (2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane

There total 4 articles about (2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 165683-83-0
(2S,3S)-3-tert-butoxycarbonylamino-1-tert-butyldimethylsilyloxy-3-phenyl-2-propanol

: 62-23-7
4-nitro-benzoic acid

: 174282-99-6
(2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In benzene; for 12h; Ambient temperature;
DOI:10.1016/0957-4166(95)00442-4

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174282-99-6
(2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / H₂ / 20percent Pd(OH)2/C / ethyl acetate / 760 Torr

2: 89 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 71 percent / PPh₃, DEAD / benzene / 12 h / Ambient temperature

With 1H-imidazole; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium dihydroxide; In ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0957-4166(95)00442-4

Reference yield:

: (2S,3S)-3-benzhydrylamino-3-phenyl-1,2-propanediol

: 174282-99-6
(2R,3S)-1-tert-butyldimethylsilyloxy-3-tert-butoxycarbonylamino-2-p-nitrophenylcarbonyloxy-3-phenylpropane

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / H₂ / 20percent Pd(OH)2/C / ethyl acetate / 760 Torr

2: 89 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

3: 71 percent / PPh₃, DEAD / benzene / 12 h / Ambient temperature

With 1H-imidazole; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium dihydroxide; In ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0957-4166(95)00442-4