adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate

Base Information

• Chemical Name: adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate
• CAS No.: 1619925-55-1
• Molecular Formula: C₁₉H₂₅O₄P
• Molecular Weight: 348.379
• Mol file: 1619925-55-1.mol

Synonyms:adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate

Chemical Property of adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate

There total 3 articles about adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-Adamantyl phosphorodichloridite (77075-02-6) + 4-(ethoxycarbonyl)phenylmagnesium bromide → adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate (1619925-55-1)

Guidance literature:

1-Adamantyl phosphorodichloridite; 4-(ethoxycarbonyl)phenylmagnesium bromide; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

With water; In tetrahydrofuran; hexane; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00548

Reference yield:

1-adamanthanol (768-95-6) → adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate (1619925-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus trichloride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran; hexane / 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

With phosphorus trichloride; In tetrahydrofuran; hexane;

DOI:10.1021/acs.joc.5b00548

Reference yield:

→ adamantyl hydrogen(4-(ethyloxycarbonyl)phenyl)phosphinate (1619925-55-1)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; hexane; at -50 - 20 ℃; for 15h;

upstream raw materials:

1-Adamantyl phosphorodichloridite

1-adamanthanol