TM5441

Base Information

Chemical Name:TM5441
CAS No.:1190221-43-2
Molecular Formula:C₂₁H₁₇ClN₂O₆
Molecular Weight:428.829
Hs Code.:
Mol file:1190221-43-2.mol

Synonyms:5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoehtoxy)acetyl]amino)benzoic acid

Suppliers and Price of TM5441

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TM5441
5mg
$ 215.00

Tocris
TM5441 ≥98%(HPLC)
10
$ 203.00

DC Chemicals
TM5441 >98%
100 mg
$ 550.00

ChemScene
TM5441 98.18%
100mg
$ 1140.00

ChemScene
TM5441 98.18%
50mg
$ 780.00

ChemScene
TM5441 98.18%
5mg
$ 144.00

ChemScene
TM5441 98.18%
2mg
$ 96.00

ChemScene
TM5441 98.18%
25mg
$ 456.00

ChemScene
TM5441 98.18%
10mg
$ 216.00

Cayman Chemical
TM5441 ≥98%
10mg
$ 175.00

Total 8 raw suppliers

Chemical Property of TM5441

Chemical Property:

Boiling Point:738.6±60.0 °C(Predicted)
PKA:2.87±0.10(Predicted)
Density:1.451±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

TM5441 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses TM5441 is a novel plasminogen activator inhibitor 1 (PAI-1). A therapeutic agent for obesity and obesity-related metabolic disorders.

Technology Process of TM5441

There total 3 articles about TM5441 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1190222-68-4
methyl 5-chloro-2-{[(2-{[3-(furan-3-yl)phenyl]amino}-2-oxoethoxy)acetyl]amino}benzoate

: 1190221-43-2
5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoehtoxy)acetyl]amino)benzoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 50 ℃; for 3h;
DOI:10.1016/j.bmcl.2017.11.016

Reference yield: 90.0%

: 1190221-43-2
5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoehtoxy)acetyl]amino)benzoic acid

Guidance literature:

Reference yield:

: 1103929-71-0
(2-{[4-chloro-2-(methoxycarbonyl)phenyl]amino}-2-oxoethoxy)acetic acid

: 1190221-43-2
5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoehtoxy)acetyl]amino)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl acetamide / 20 °C

2: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2017.11.016