(E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester

Base Information

Chemical Name:(E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester
CAS No.:1623145-68-5
Molecular Formula:C₁₃H₁₃F₃O₃
Molecular Weight:274.24
Hs Code.:

Synonyms:(E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester

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Chemical Property of (E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester

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Technology Process of (E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester

There total 3 articles about (E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₁F₃O₃Si

: 1623145-68-5
(E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 4h;
DOI:10.1016/j.tetasy.2014.06.013

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 1623145-68-5
(E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester

: (S,E)-ethyl 2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-enoate

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}; In chloroform; at 100 ℃; for 40h; Solvent; Reagent/catalyst; Overall yield = 70 %; Overall yield = 38.3 mg; enantioselective reaction; Schlenk technique; Sealed tube;
DOI:10.1021/acs.joc.6b00358

Reference yield:

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 18001-47-3
styryltrimethylsilane

: 1623145-68-5
(E,R)-2-hydroxy-4-phenyl-2-trifluoromethyl-but-3-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: C₄₄H₃₂P₂Pd⁽²⁺⁾*2F₆Sb^(1-) / dichloromethane / 24 h / 0 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran; water / 4 h / 20 °C

With hydrogenchloride; C₄₄H₃₂P₂Pd⁽²⁺⁾*2F₆Sb^(1-); In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetasy.2014.06.013