Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester

Base Information

• Chemical Name: Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester
• CAS No.: 154047-95-7
• Molecular Formula: C₂₇H₂₄O₁₀S
• Molecular Weight: 540.548
• Mol file: 154047-95-7.mol

Synonyms:Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester

Chemical Property of Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester

There total 6 articles about Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

p-toluenesulfonyl chloride (98-59-9) + 6-acetoxy-5-hydroxy-3,4',7-trimethoxyflavone (154047-87-7) → Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester (154047-95-7)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1246/bcsj.66.2668

Reference yield:

5,6-dihydroxy-3,4',7-trimethoxyflavone diacetate (154047-82-2) → Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester (154047-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / AlBr₃ / acetonitrile

2: 87 percent / potassium carbonate / acetone / Heating

With aluminum tri-bromide; potassium carbonate; In acetone; acetonitrile;

DOI:10.1246/bcsj.66.2668

Reference yield:

5,6-dihydroxy-3,7,4′-trimethoxyflavonol (84019-17-0) → Acetic acid 3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-5-(toluene-4-sulfonyloxy)-4H-chromen-6-yl ester (154047-95-7)

Guidance literature:

Multi-step reaction with 4 steps

1: i-Pr₂NEt / CH₂Cl₂ / 3 h / 5 - 10 °C

2: K₂CO₃ / acetone / 3 h / Heating

3: conc. aq. HCl, AcOH / 2 h / Ambient temperature

4: pyridine / Heating

With pyridine; hydrogenchloride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1248/cpb.45.1573

upstream raw materials:

p-toluenesulfonyl chloride

6-acetoxy-5-hydroxy-3,4',7-trimethoxyflavone

acetic anhydride

Toluene-4-sulfonic acid 6-hydroxy-3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-5-yl ester

Downstream raw materials:

Toluene-4-sulfonic acid 3,6-dihydroxy-7-methoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-5-yl ester

3,5-Dihydroxy-7-methoxy-6-methoxymethoxy-2-(4-methoxy-phenyl)-chromen-4-one

6-hydroxykaempferol 7,4'-dimethyl ether

Toluene-4-sulfonic acid 6-hydroxy-3,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-5-yl ester