N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide

Base Information

• Chemical Name: N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide
• CAS No.: 92740-32-4
• Molecular Formula: C₂₆H₃₁N₅O₄S*HI
• Molecular Weight: 637.542
• Mol file: 92740-32-4.mol

Synonyms:N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide

Chemical Property of N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide

There total 8 articles about N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-{2-Butylcarbamoyl-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide (92740-71-1) → N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide (92740-32-4)

Guidance literature:

With ammonium acetate; In methanol; at 60 ℃; for 2.5h;

Reference yield:

N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester (52117-01-8) → N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide (92740-32-4)

Guidance literature:

Multi-step reaction with 7 steps

1: NaOH (1 mol/l) / acetic acid; H₂O / pH 3.8-4.0

2: NaOH (1 mol/l) / diethyl ether; ethyl acetate; H₂O / 10 h

3: DCC / pyridine / 12 h / Ambient temperature

4: 55 percent / pyridine; dimethylformamide / 7 h / Ambient temperature

5: 85 percent / H₂S, TEA / pyridine / 72 h / Ambient temperature

6: 80 percent / acetone / 0.17 h / Heating

7: 90 percent / CH₃COONH₄ / methanol / 2.5 h / 60 °C

With sodium hydroxide; TEA; hydrogen sulfide; ammonium acetate; dicyclohexyl-carbodiimide; In pyridine; methanol; diethyl ether; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

α-naphthylenesulfonylglycine (92740-47-1) → N-Butyl-3-(4-carbamimidoyl-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide; hydriodide (92740-32-4)

Guidance literature:

Multi-step reaction with 7 steps

1: SOCl₂ / 1 h / Heating

2: NaOH (1 mol/l) / diethyl ether; ethyl acetate; H₂O / 10 h

3: DCC / pyridine / 12 h / Ambient temperature

4: 55 percent / pyridine; dimethylformamide / 7 h / Ambient temperature

5: 85 percent / H₂S, TEA / pyridine / 72 h / Ambient temperature

6: 80 percent / acetone / 0.17 h / Heating

7: 90 percent / CH₃COONH₄ / methanol / 2.5 h / 60 °C

With sodium hydroxide; thionyl chloride; TEA; hydrogen sulfide; ammonium acetate; dicyclohexyl-carbodiimide; In pyridine; methanol; diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

upstream raw materials:

4-{2-Butylcarbamoyl-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-ethyl}-thiobenzimidic acid methyl ester; hydriodide

N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester

α-naphthylenesulfonylglycine

N-Butyl-3-(4-cyano-phenyl)-2-[2-(naphthalene-1-sulfonylamino)-acetylamino]-propionamide