6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine

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Chemical Name:6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine
CAS No.:1069131-89-0
Molecular Formula:C₁₇H₁₆BrIN₄O
Molecular Weight:499.149
Hs Code.:

Synonyms:6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine

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Chemical Property of 6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine

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Technology Process of 6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine

There total 7 articles about 6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1069131-87-8
6-bromo-7-iodo-2-[4-(morpholin-4-ylcarbonyl)phenyl]-3H-imidazo[4,5-b]pyridine

: 1069131-89-0
6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine

Guidance literature:: 6-bromo-7-iodo-2-[4-(morpholin-4-ylcarbonyl)phenyl]-3H-imidazo[4,5-b]pyridine; With borane-THF; In tetrahydrofuran; at 20 ℃; for 1.5h;

With methanol; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1069131-80-1
methyl 4-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate

: 1069131-89-0
6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; 3-chloro-benzenecarboperoxoic acid / 24 h / 20 °C

1.2: 0.08 h / 120 °C / Microwave irradiation

2.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

2.2: 0.33 h / 160 °C / Microwave irradiation

3.1: lithium hydroxide; water / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

4.1: O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.75 h / 20 °C

4.2: 5 h / 20 °C

5.1: borane-THF / tetrahydrofuran / 1.5 h / 20 °C

5.2: 16 h / 20 °C

With hydrogenchloride; lithium hydroxide; borane-THF; water; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1069131-83-4
methyl 4-(6-bromo-7-iodo-3H-imidazo[4,5-b]pyridin-2-yl)benzoate

: 1069131-89-0
6-bromo-7-iodo-2-[4-(morpholin-4-ylmethyl)phenyl]-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 0.17 h / 100 °C / Microwave irradiation

2.1: O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 0.75 h / 20 °C

2.2: 5 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 1.5 h / 20 °C

3.2: 16 h / 20 °C

With lithium hydroxide; borane-THF; water; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;