(4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride

Base Information

Chemical Name:(4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride
CAS No.:117498-93-8
Molecular Formula:C₁₂H₉N₃O₅S*ClH
Molecular Weight:343.748
Hs Code.:

Synonyms:(4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride

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Chemical Property of (4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride

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Technology Process of (4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride

There total 6 articles about (4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 117498-51-8
<4-<<(tert-butoxycarbonyl)amino>methyl>-2-thienyl>(3,4-dinitrophenyl)methanone

: 117498-93-8
(4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 0.5h; Ambient temperature;
DOI:10.1021/jm00122a020

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 117498-93-8
(4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 12 h / Heating

2: AlCl₃ / CH₂Cl₂ / 2.5 h / Heating

3: 78 percent / 45percent sulfuric aicd / 4.5 h / Heating

4: thionyl chloride / 3 h / Heating

5: 1.) azidotrimethylsilane / 1.) toluene, reflux, 16 h, 2.) reflux, 6 h

6: 98 percent / 3M HCl / ethyl acetate / 0.5 h / Ambient temperature

With hydrogenchloride; aluminium trichloride; thionyl chloride; trimethylsilylazide; sulfuric acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00122a020

Reference yield:

: 24376-18-9
3,4-dinitrobenzoyl chloride

: 117498-93-8
(4-Aminomethyl-thiophen-2-yl)-(3,4-dinitro-phenyl)-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / CH₂Cl₂ / 2.5 h / Heating

2: 78 percent / 45percent sulfuric aicd / 4.5 h / Heating

3: thionyl chloride / 3 h / Heating

4: 1.) azidotrimethylsilane / 1.) toluene, reflux, 16 h, 2.) reflux, 6 h

5: 98 percent / 3M HCl / ethyl acetate / 0.5 h / Ambient temperature

With hydrogenchloride; aluminium trichloride; thionyl chloride; trimethylsilylazide; sulfuric acid; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00122a020