3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one

Base Information

• Chemical Name: 3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one
• CAS No.: 1418303-25-9
• Molecular Formula: C₁₃H₁₁F₃O₂
• Molecular Weight: 256.224
• Mol file: 1418303-25-9.mol

Synonyms:3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one

Chemical Property of 3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one

There total 1 articles about 3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

m-trifluoromethylphenyl iodide (401-81-0) + 1,3-cylohexanedione (504-02-9) → 3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one (1418303-25-9)

Guidance literature:

With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 90 ℃; for 48h; Inert atmosphere;

DOI:10.1002/anie.201207170

Reference yield: 66.0%

1-Phenylprop-1-yne (673-32-5) + 3-hydroxy-2-[3-(trifluoromethyl)phenyl]cyclohex-2-en-1-one (1418303-25-9) → 3'-methyl-2'-phenyl-6'-(trifluoromethyl)spiro[cyclohexane-1,1'-indene]-2,6-dione (1439383-26-2)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper diacetate; In 1,4-dioxane; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201207170

upstream raw materials:

m-trifluoromethylphenyl iodide

1,3-cylohexanedione

Downstream raw materials:

3'-methyl-2'-phenyl-6'-(trifluoromethyl)spiro[cyclohexane-1,1'-indene]-2,6-dione