(4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol

Base Information

Chemical Name:(4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol
CAS No.:1374584-24-3
Molecular Formula:C₂₁H₁₉ClFNO₂
Molecular Weight:371.839
Hs Code.:

Synonyms:(4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol

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Chemical Property of (4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol

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Technology Process of (4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol

There total 3 articles about (4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 14548-44-8
3-(4-chlorobenzoyl)pyridine

: 1036724-61-4
1-bromo-2-fluoro-4-(isopropoxy)benzene

: 1374584-24-3
(4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol

Guidance literature:: 1-bromo-2-fluoro-4-(isopropoxy)benzene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 2h;

3-(4-chlorobenzoyl)pyridine; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃;
DOI:10.1021/jm2015809

Reference yield:

: 121219-03-2
4-bromo-3-fluorophenol

: 1374584-24-3
(4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C

2.2: -78 - 20 °C

With n-butyllithium; potassium carbonate; In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm2015809

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 1374584-24-3
(4-chlorophenyl)(2-fluoro-4-(propan-2-yloxy)phenyl)pyridin-3-yl methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 1.5 h / -70 - -60 °C / Inert atmosphere; Cooling with acetone-dry ice

1.2: 4.5 h / -70 - 20 °C / Inert atmosphere; Cooling with acetone-dry ice

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C

2.2: -78 - 20 °C

With n-butyllithium; In diethyl ether; hexane;
DOI:10.1021/jm2015809