6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Base Information

Chemical Name:6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol
CAS No.:861930-36-1
Molecular Formula:C₂₉H₂₈FNO₃
Molecular Weight:457.545
Hs Code.:

Synonyms:6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

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Chemical Property of 6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

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Technology Process of 6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

There total 9 articles about 6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1-(2-{4-[2-(3-fluoro-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine hydrochloride

: 861930-36-1
6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 648904-47-6
2-(benzyloxy)-1-bromo-6-methoxynaphthalene

: 861930-36-1
6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 30 percent / copper triflate

2: NH₄HCO₂ / Pd(OH)2

3: PCy₃; CsF / Pd(OAc)2

4: BBr₃

With ammonium formate; boron tribromide; copper(I) triflate; cesium fluoride; tricyclohexylphosphine; palladium diacetate; palladium dihydroxide; 1: Ullman coupling / 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044

Reference yield:

: 648904-49-8
6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol

: 861930-36-1
6-(3-fluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: PCy₃; CsF / Pd(OAc)2

2: BBr₃

With boron tribromide; cesium fluoride; tricyclohexylphosphine; palladium diacetate; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.044