(2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

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Chemical Name:(2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide
CAS No.:1314801-95-0
Molecular Formula:C₂₅H₂₂N₄O₂
Molecular Weight:410.475
Hs Code.:

Synonyms:(2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

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Chemical Property of (2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

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Technology Process of (2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

There total 8 articles about (2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1314802-34-0
(2E)-N-(4-methoxybenzyloxy)-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

: 1314801-95-0
(2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.04.027

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 1314801-95-0
(2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran / 1 h / -15 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

3.1: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4.1: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 20 °C

With n-butyllithium; triethylphosphite copper(I) iodide complex; chlorotriisopropylsilane; diphenyl phosphoryl azide; potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2011.04.027

Reference yield:

: 1092115-32-6
(E)-N-(4-methoxybenzyloxy)-5-(trimethylsilyl)pent-2-en-4-ynamide

: 1314801-95-0
(2E)-N-hydroxy-3-(1-((E)-1-(naphthalen-1-yl)-4-phenylbut-3-en-2-yl)-1H-1,2,3-triazol-4-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride

2: triethylphosphite copper(I) iodide complex; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 20 °C

With triethylphosphite copper(I) iodide complex; chlorotriisopropylsilane; N-ethyl-N,N-diisopropylamine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.04.027