N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide

Base Information

• Chemical Name: N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide
• CAS No.: 1329995-79-0
• Molecular Formula: C₂₇H₄₀N₄O₄
• Molecular Weight: 484.639
• Mol file: 1329995-79-0.mol

Synonyms:N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide

Chemical Property of N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide

There total 2 articles about N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N-{2-[(3-hydroxyphenyl)(methylamino)]ethyl}acetamide (203580-73-8) + 1,5-dibromo-pentane (111-24-0) → N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide (1329995-79-0)

Guidance literature:

N-{2-[(3-hydroxyphenyl)(methylamino)]ethyl}acetamide; With potassium carbonate; In acetonitrile; for 0.5h; Reflux;

1,5-dibromo-pentane; In acetonitrile; for 16h; Reflux;

DOI:10.1016/j.bmc.2011.06.063

Reference yield:

N-(2-((3-methoxyphenyl)(methyl)amino)ethyl)acetamide → N-(2-{[3-(5-{3-[(2-acetylaminoethyl)methylamino]phenoxy}pentyloxy)phenyl]methylamino}ethyl)acetamide (1329995-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 18 h / 0 - 20 °C

1.2: Saturated solution

2.1: potassium carbonate / acetonitrile / 0.5 h / Reflux

2.2: 16 h / Reflux

With boron tribromide; potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2011.06.063

upstream raw materials:

N-{2-[(3-hydroxyphenyl)(methylamino)]ethyl}acetamide

1,5-dibromo-pentane