2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:852683-09-1
Molecular Formula:C₃₈H₆₀FN₅O₅
Molecular Weight:685.923
Hs Code.:

2-[2-(4-<i>tert</i>-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

There total 9 articles about 2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 852682-71-4
5-ethyl-4-methyl-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

: 363191-04-2
1-[(2R)-2-amino-3-(4-fluorophenyl)-1-oxopropyl]-4-cyclohexyl-N-(1,1-dimethylethyl)-4-piperidine carboxamide

: 852683-09-1
2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2005.02.068

Reference yield:

: 852683-07-9
(S)-1-Benzyl-5-ethyl-4-methyl-piperazine-2-carboxylic acid methyl ester

: 852683-09-1
2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / H₂; HCl / Pd/C / ethanol

2: 83 percent / TEA / CH₂Cl₂

3: 100 percent / aq. NaOH / methanol

4: 84 percent / EDC; HOBt; DIEA / CH₂Cl₂

With hydrogenchloride; sodium hydroxide; TEA; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.02.068

Reference yield:

: 852682-69-0
(S)-1-Benzyl-5-ethyl-piperazine-2-carboxylic acid methyl ester

: 852683-09-1
2-[2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-5-ethyl-4-methyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / NaCNBH₃; NaOAc; TFA / methanol

2: 55 percent / H₂; HCl / Pd/C / ethanol

3: 83 percent / TEA / CH₂Cl₂

4: 100 percent / aq. NaOH / methanol

5: 84 percent / EDC; HOBt; DIEA / CH₂Cl₂

With hydrogenchloride; sodium hydroxide; TEA; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.02.068