1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide

Base Information

• Chemical Name: 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide
• CAS No.: 1350730-22-1
• Molecular Formula: C₂₂H₂₁Cl₂N₅O
• Molecular Weight: 442.348
• Mol file: 1350730-22-1.mol

Synonyms:1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide

Chemical Property of 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide

There total 4 articles about 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carboxylate (1350730-47-0) → 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide (1350730-22-1)

Guidance literature:

With hydrazine hydrate; In methanol; Reflux;

DOI:10.1016/j.ejmech.2011.09.049

Reference yield:

C14H13N3O2 (51843-30-2) → 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide (1350730-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium bromide; potassium hydroxide / dimethyl sulfoxide / 1.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 10 °C

2.2: 1 h / 10 - 20 °C

3.1: hydrazine hydrate / methanol / Reflux

With sodium hydride; hydrazine hydrate; potassium bromide; potassium hydroxide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.09.049

Reference yield:

ethyl 1-(2,4-dichlorobenzyl)-3-(1H-indol-3-yl)-1H-pyrazole-5-carboxylate (1350730-37-8) → 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide (1350730-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 10 °C

1.2: 1 h / 10 - 20 °C

2.1: hydrazine hydrate / methanol / Reflux

With sodium hydride; hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.09.049

upstream raw materials:

ethyl 1-(2,4-dichlorobenzyl)-3-(1H-indol-3-yl)-1H-pyrazole-5-carboxylate

C₁₄H₁₃N₃O₂

ethyl 1-(2,4-dichlorobenzyl)-3-(1-propyl-1H-indol-3-yl)-1H-pyrazole-5-carboxylate

2,4-Dichlorobenzyl chloride